Role of capsaicin, circadian clock genes, and TRPV1 in colorectal carcinogenesis: Lessons and future directions

作者：Qiuyan Zhang, Yujia Lu, Yuchen Zhao, Chi‐Tang Ho, Yuhao Zhang, Yu Fu · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.10.004 · 被引用次数：1 · 研究领域：Circadian rhythm and melatonin、Dietary Effects on Health、Herbal Medicine Research Studies

• Circadian misalignment is closely linked to colorectal cancer (CRC) progression. • Capsaicin can modulate circadian clock genes with potential anti-CRC effects. • TRPV1-dependent and TRPV1-independent routes are two main mechanisms. Disruptions in rhythm-regulating genes, termed circadian misalignment, have been increasingly associated with the progression of colorectal cancer (CRC), a significant global health challenge. Capsaicin (CAP), a bioactive compound found in chili pepper, has emerged as a promising modulator of clock genes, exhibiting anti-CRC potential. We propose a previously unrecognized dual-pathway mechanism where CAP may modulate circadian clock genes via both transient receptor potential vanilloid 1 (TRPV1)-dependent and TRPV1-independent pathways to inhibit colorectal carcinogenesis. Although the role of CAP in CRC prevention via clock gene regulation is compelling, direct mechanistic evidence remains limited. This paper also identifies several research gaps to underscore the necessity for further research to unlock its therapeutic potential and develop novel preventive strategies.