Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

作者：Ronald P. de Vries, Robert Riley, Ad Wiebenga, Guillermo Aguilar‐Osorio, Sotiris Amillis, Cristiane Uchima, Gregor Anderluh, Mojtaba Asadollahi, Marion Askin, Kerrie Barry, Evy Battaglia, Özgür Bayram, Tiziano Benocci, Susanna A. Braus‐Stromeyer, Camila Caldana, David Cánovas, Gustavo Cerqueira, Fusheng Chen, Wan‐Ping Chen, Cindy Choi, Alicia Clum, Renato Santos, André Damásio, George Diallinas, Tamás Emri, Erzsébet Fekete, Michel Flipphi, Susanne Freyberg, Antonia Gallo, Christos Gournas, Rob Habgood, Matthieu Hainaut, María Laura Harispe, Bernard Henrissat, Kristiina Hildén, Ryan Hope, Abeer Hossain, Eugenia Karabika, Levente Karaffa, Zsolt Karányi, Nada Kraševec, Alan Kuo, Harald Kusch, Kurt LaButti, Ellen L. Lagendijk, Alla Lapidus, Anthony Levasseur, Erika Lindquist, Anna Lipzen, Antonio Logrieco, Andrew MacCabe, Miia Mäkelä, Iran Malavazi, Petter Melin, Vera Meyer, Natalia Mielnichuk, Márton Miskei, Ákos Molnár, Giuseppina Mulè, Chew Yee Ngan, Margarita Orejas, Erzsébet Orosz, Jean Ouedraogo, Karin Overkamp, Hee-Soo Park, Giancarlo Perrone, François Piumi, Peter J. Punt, Arthur F. J. Ram, Ana Ramón, Stefan Rauscher, Éric Record, Diego Mauricio Riaño‐Pachón, Vincent Robert, Julian Röhrig, Roberto Ruller, Asaf Salamov, Nadhira S. Salih, Robert A. Samson, Erzsébet Sándor, Manuel Sanguinetti, Tabea Schütze, Kristina Sepčić, Ekaterina Shelest, Gavin Sherlock, Vicky Sophianopoulou, Fábio M. Squina, Hui Sun, Antonia Susca, Richard B. Todd, Adrian Tsang, Shiela E. Unkles, Nathalie van de Wiele, Diana van Rossen-Uffink, Juliana Oliveira, Tammi Vesth, Jaap Visser, Jae‐Hyuk Yu, Miaomiao Zhou, Mikael Rørdam Andersen, David B. Archer, Scott Baker, Isabelle Benoit, Axel A. Brakhage, Gerhard H. Braus, Rainer Fischer, Jens C. Frisvad, Gustavo H. Goldman, Jos Houbraken, Berl R. Oakley, István Pócsi, Claudio Scazzocchio, Bernhard Seiboth, Patricia vanKuyk, Jennifer R. Wortman, Paul S. Dyer, Igor V. Grigoriev · 发表于：Genome biology · 年份：2017 · DOI：10.1186/s13059-017-1151-0 · 被引用次数：518 · 研究领域：Fungal and yeast genetics research、Mycotoxins in Agriculture and Food、Yeasts and Rust Fungi Studies

BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. CONCLUSIONS: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, ...