Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

作者：Suvi T. M. Orr, Sharon L. Ripp, T. Eric Ballard, Jaclyn L. Henderson, Dennis O. Scott, R. Scott Obach, Hao Sun, Amit S. Kalgutkar · 发表于：Journal of Medicinal Chemistry · 年份：2012 · DOI：10.1021/jm300065h · 被引用次数：220 · 研究领域：Pharmacogenetics and Drug Metabolism、Drug Transport and Resistance Mechanisms、Computational Drug Discovery Methods

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTMechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction RisksSuvi T. M. Orr†, Sharon L. Ripp‡, T. Eric Ballard†, Jaclyn L. Henderson†, Dennis O. Scott§, R. Scott Obach‡, Hao Sun‡, and Amit S. Kalgutkar*§View Author Information‡ †Worldwide Medicinal Chemistry and ‡Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States§ Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, Massachusetts 02139, United States*Phone: (617) 551-3336. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 11, 4896–4933Publication Date (Web):March 12, 2012Publication History Received15 January 2012Published online27 March 2012Published inissue 14 June 2012https://pubs.acs.org/doi/10.1021/jm300065hhttps://doi.org/10.1021/jm300065hreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views13560Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Cros...