Dennis O. Scott

机构：Pfizer (United States) · ORCID：0000-0003-1385-6812

发表论文 65 篇 · 总被引 2791 次 · h-index 31

代表论文

• Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks (2012 · Journal of Medicinal Chemistry · 被引 220)
• Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design (2012 · European Journal of Medicinal Chemistry · 被引 155)
• Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells (2015 · Drug Metabolism and Disposition · 被引 66)
• Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis (2017 · Angewandte Chemie International Edition · 被引 46)
• Systematic and Pairwise Analysis of the Effects of Aromatic Halogenation and Trifluoromethyl Substitution on Human Liver Microsomal Clearance (2011 · Drug Metabolism Letters · 被引 44)
• Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters (2016 · Clinical Pharmacology & Therapeutics · 被引 42)