The clinical anti-inflammatory effects and underlying mechanisms of silymarin

作者：Yuqi Zhao, Yingyu Zhou, Ting Gong, Zhiting Liu, Wanying Yang, Yi Xiong, Dan Xiao, Alejandro Cifuentes, Elena Ibáñez, Weihong Lu · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.111109 · 被引用次数：34 · 研究领域：Silymarin and Mushroom Poisoning、Drug-Induced Hepatotoxicity and Protection、Curcumin's Biomedical Applications

seeds and fruits, has shown efficacy in treating a range of liver diseases. The expanding corpus of research on silymarin highlights its promising role in preventing and managing inflammatory conditions and autoimmune without adverse effects. This review discusses the absorption, metabolism, and anti-inflammatory mechanisms of silymarin, exploring its impact on the secretion of inflammatory factors, such as nuclear factor kappa B (NF-κB) pathway, mitogen-activated protein kinase (MAPK) pathway, and antioxidant pathway. We delve into its disease-modifying potential for clinical applications, thereby laying a theoretical foundation for further silymarin research and clinical studies.