Structural characterization, acute toxicity assessment and protective effects of selenylated apple pectin on dextran sulfate sodium-induced ulcerative colitis

作者：Wen Tao, Xiaoyu An, Ziqi Guo, Ning Yang, Muci Wu, Hélder Oliveira, Rui Zhang, Jingren He · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d1fo04189d · 被引用次数：15 · 研究领域：Selenium in Biological Systems、Curcumin's Biomedical Applications、Aluminum toxicity and tolerance in plants and animals

-O group) at 3-4 ppm were observed after selenylation. The selenylated apple pectin showed the protective effect against UC by down-regulating IL-6 and TNF-α contents and up-regulating the IL-10 content in serum, as well as increasing the GSH-Px activity and decreasing the MPO content in colon tissues. Moreover, DSS-induced alterations were effectively recovered by a high-dose sample. These findings provide evidence in support of selenylated apple pectin as a novel dietary selenium supplement for UC protection.