Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet

作者：Weiling Guo, Jianbin Guo, Binyu Liu, Jin-Qiang Lu, Min Chen, Bin Liu, Weidong Bai, Pingfan Rao, Li Ni, Xu‐Cong Lv · 发表于：Food & Function · 年份：2020 · DOI：10.1039/d0fo00436g · 被引用次数：97 · 研究领域：Fungal Biology and Applications、Gut microbiota and health、Pharmacological Effects of Natural Compounds

), compared with the HFD-fed hyperlipidemic mice. Metabolic pathway enrichment analysis of the differential hepatic metabolites demonstrated that GA intervention had significant regulatory effects on primary bile acid biosynthesis, fatty acid biosynthesis, amino sugar and nucleotide sugar metabolism, inositol phosphate metabolism, and so on. In addition, GA intervention regulated the mRNA levels of hepatic genes involved in fatty acid metabolism and bile acid homeostasis. These findings present new evidence supporting that GA from G. lucidum has the potential to alleviate lipid metabolic disorders and ameliorate the imbalance of gut microflora in a positive way.