BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

作者：William Farnaby, Manfred Koegl, Michael J. Roy, Claire Whitworth, Emelyne Diers, Nicole B. Trainor, David Zollman, Steffen Steurer, Jale Karolyi‐Oezguer, Carina Riedmueller, Teresa Gmaschitz, Johannes Wachter, Christian Dank, Michael Galant, Bernadette Sharps, Klaus Rumpel, Elisabeth Traxler, Thomas Gerstberger, Renate Schnitzer, Oliver Petermann, Peter Greb, Harald Weinstabl, Gerd Bader, Andreas Zoephel, Alexander Weiss-Puxbaum, Katharina Ehrenhöfer-Wölfer, Simon Wöhrle, Guido Boehmelt, Joerg Rinnenthal, Heribert Arnhof, Nicola Wiechens, Mengying Wu, Tom Owen‐Hughes, Peter Ettmayer, Mark A. Pearson, Darryl B. McConnell, Alessio Ciulli · 发表于：Nature Chemical Biology · 年份：2019 · DOI：10.1038/s41589-019-0294-6 · 被引用次数：589 · 研究领域：Protein Degradation and Inhibitors、Chromatin Remodeling and Cancer、Peptidase Inhibition and Analysis