Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

作者：Zhilei Shan, Hongfei Ma, Manling Xie, Peipei Yan, Yanjun Guo, Wei Bao, Rong Ying, Chandra L. Jackson, Frank B. Hu, Liegang Liu · 发表于：Diabetes Care · 年份：2015 · DOI：10.2337/dc14-2073 · 被引用次数：917 · 研究领域：Sleep and related disorders、Sleep and Work-Related Fatigue、Dietary Effects on Health

OBJECTIVE: It remains unclear how many hours of sleep are associated with the lowest risk of type 2 diabetes. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: PubMed and Embase were searched up to 20 March 2014 for prospective observational studies that assessed the relationship of sleep duration and risk of type 2 diabetes. Both semiparametric and parametric methods were used. RESULTS: Ten articles with 11 reports were eligible for inclusion in the meta-analysis. A total of 18,443 incident cases of type 2 diabetes were ascertained among 482,502 participants with follow-up periods ranging from 2.5 to 16 years. A U-shaped dose-response relationship was observed between sleep duration and risk of type 2 diabetes, with the lowest risk observed at a sleep duration category of 7-8 h per day. Compared with 7-h sleep duration per day, the pooled relative risks for type 2 diabetes were 1.09 (95% CI 1.04-1.15) for each 1-h shorter sleep duration among individuals who slept <7 h per day and 1.14 (1.03-1.26) for each 1-h increment of sleep duration among individuals with longer sleep duration. CONCLUSIONS: Our dose-response meta-analysis of prospective studies shows a U-shaped relationship between sleep duration and risk of type 2 diabetes, with the lowest type 2 diabetes risk at 7-8 h per day of sleep duration. Both short and long sleep duration are associated with a significantly ...