Targeted and non-targeted analysis of contaminants from food contact materials by LC-QTOF-MS coupled with QSRR modeling

作者：Ziyun Xu · 发表于：Open MIND · 年份：2025 · DOI：10.82308/11252 · 研究领域：Effects and risks of endocrine disrupting chemicals、Dye analysis and toxicity、Toxic Organic Pollutants Impact

Growing concerns about food contact materials (FCMs) due to the migration of harmful substances, including bisphenols, per- and polyfluoroalkyl substances (PFAS), and various unknown contaminants into food. The conventional method for detecting known food contaminants is "targeted analysis," which relies on predefined information (e.g., exact mass or structural data) to detect and quantify analytes. However, non-intentionally added substances (NIAS), including both unexpected and unknown contaminants, require a novel approach. Non-targeted analysis, notably based on high-performance liquid chromatography-mass spectrometry (HPLC-MS) coupled with advanced data mining techniques, has the potential to identify unknown contaminants. The overall objective of this research was to improve the surveillance and safety of food contact materials through the development and application of novel LC-QTOF-MS strategies to analyze known and unknown migrants (NIAS). Chapter 3 of the study involved the analysis of 140 packaging materials from fresh food in North America, with a particular focus on the occurrence and migration of bisphenol A (BPA), bisphenol S (BPS), and other color developers in thermal labels through targeted analysis. While no detectable BPA was found in the samples, significant levels of BPS and other developers were identified. Controlled experiments demonstrated that BPS, along with other developers such as D-8, D-90, and Pergafast-201, could migrate into food. Notably, BP...