Multi-targeted protection of Yuping Tongqiao against allergic rhinitis: suppression of inflammatory response via TSLP signaling and reinforcement of epithelial barrier integrity via AhR signaling

作者：Zhixin Wang, Jingqi Cai, Jiahao Wu, Haoran Zheng, Min Shi, Yanan Tong, Yunlong Hou, Zhenhua Jia, Hui Qi · 发表于：Frontiers in Allergy · 年份：2026 · DOI：10.3389/falgy.2026.1824120 · 被引用次数：1 · 研究领域：Allergic Rhinitis and Sensitization、Asthma and respiratory diseases、Dermatology and Skin Diseases

Background Allergic rhinitis (AR) is a prevalent chronic inflammatory disorder characterized by persistent inflammation and nasal epithelial barrier disruption. Restoring epithelial integrity and modulating the inflammatory cascade are considered promising therapeutic strategies for AR. Purpose This study aims to systematically investigate the therapeutic efficacy of Yuping Tongqiao Tablet (YPTQ), a traditional Chinese medicine formula, in the treatment of AR and to decipher its potential mechanisms and active ingredients focusing on inflammation amelioration and barrier restoration. Methods An AR model was established in Sprague-Dawley rats that were sensitized and challenged with OVA. After intervention with different doses of YPTQ, nasal pathological injury and inflammatory cell infiltration were evaluated. In vitro , a human nasal epithelial cell (RPMI-2650) injury model was induced using house dust mites (HDM). Following YPTQ treatment, the expression levels of inflammatory factors and barrier-related proteins were assessed. Furthermore, the potential mechanisms and targets of YPTQ and its active monomers against AR were investigated by integrating network pharmacology analysis and molecular docking with in vitro experiments. Results In the OVA-induced AR rat model, YPTQ effectively alleviated nasal symptoms, reduced histopathological damage and inflammatory cell infiltration, and suppressed overall inflammatory levels. In the HDM-induced RPMI-2650 cell injury model, YPT...