Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes

作者：Pei Zhong, Ao Ren, Junwei Cui, Cheng Guo, Yanmei Zhang, Qiyu Diao, Xianjun Liu, Naifeng Zhang, Yan Tu, Yanliang Bi · 发表于：npj Biofilms and Microbiomes · 年份：2026 · DOI：10.1038/s41522-026-00988-8 · 被引用次数：1 · 研究领域：Milk Quality and Mastitis in Dairy Cows、Reproductive Physiology in Livestock、Effects of Environmental Stressors on Livestock

Dairy cow health involves host-microbiome interactions. This review characterized microbial landscapes across anatomical sites in dairy cows-including the gastrointestinal tract, respiratory system, reproductive tract, mammary gland, and skin-and examines their associations with diseases. We elucidated how site-specific dysbiosis drives systemic conditions such as mastitis and ketosis through inter-organ axes. Finally, we evaluated emerging microbiome-based modulation strategies and their application prospects in dairy farming.