Leveraging weighted embedding and Transformer architecture to improve phenotype prediction of complex traits for crops

作者：Jing Li, Linfeng Yu, Min Li, Rui Han, Yecheng Li, A. S. Shaibu, Kwadwo Gyapong Agyenim‐Boateng, Zhaoyi Hao, Yitian Liu, Bin Li, Shengrui Zhang, Liang Li, Lijuan Qiu, Jin Sun · 发表于：Nature Communications · 年份：2026 · DOI：10.1038/s41467-026-71035-5 · 被引用次数：2 · 研究领域：Genetic Associations and Epidemiology、Genetic Mapping and Diversity in Plants and Animals、Genetic and phenotypic traits in livestock

Understanding the relationship between genomic variation and phenotype is fundamental to deciphering the genetic architecture underlying complex traits. Yet, existing statistical models struggle to balance massive genomic datasets with biological interpretability. Here, we introduce GP-WAITER, a deep learning framework integrating GWAS-derived SNP weights into a hybrid convolutional neural network and Transformer architecture. By utilizing a weighted embedding mechanism and multi-head self-attention, GP-WAITER effectively captures long-range dependencies across ultra-long genomic sequences. The model consistently outperforms seven state-of-the-art genomic prediction models across six datasets, achieving up to a 77.5% improvement in prediction accuracy, a 78% reduction in mean squared error, and a 1.8-2.4fold increase in computational efficiency. Furthermore, GP-WAITER offers biological transparency by pinpointing key genetic variants driving specific traits. This scalable, interpretable framework provides a powerful tool for precision breeding and the functional interpretation of trait-associated variants. Available genomic prediction models lack scalability and interpretability. The authors introduce a deep learning framework that incorporates GWAS derived SNP weights into a hybrid CNN Transformer architecture, improving prediction accuracy and interpretability in soybean, maize, rice, and wheat.