Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer

作者：Yi Yang, Y. C. Xu, Xia Guo, Wen-Juan Gan, Wen-Xin Wu, Wei-Yi Shi, Xiaoshun He, Yi-Xuan Liu, Shan Wan, Zhi Jiang, Ying Liu, Xiuming Li, Zu-Da Pan, X. Zhang, Yan Xu, Xubo Gao, L. B. Guo, Guideng Li, Hua Wu · 发表于：Nature Metabolism · 年份：2026 · DOI：10.1038/s42255-026-01482-3 · 被引用次数：10 · 研究领域：Cancer Immunotherapy and Biomarkers、Proteoglycans and glycosaminoglycans research、T-cell and B-cell Immunology