Corynebacterium Striatum Infective Endocarditis: A Systematic Review

作者：Ming-Huan Hong, Wei Xiang, Lingyun Kong, Xiujuan Wang, Li Fu, Lingling Chen, Fang Liu · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s512822 · 被引用次数：2 · 研究领域：Diphtheria, Corynebacterium, and Tetanus、Infective Endocarditis Diagnosis and Management、Bacterial Identification and Susceptibility Testing

Background: Corynebacterium striatum (CS) is an uncommon but potentially fatal pathogen of infective endocarditis (IE). The literature on the patterns and clinical progression of Corynebacterium striatum infective endocarditis (CSIE) is limited. This article aims to provide insights into the clinical presentation and management of CSIE through a retrospective analysis of documented cases. Methods: An electronic search was conducted across various databases including PubMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, and Wanfang database to identify relevant articles in both English and Chinese literature documenting CSIE. Subsequently, patient-level data were extracted and subjected to analysis. Results: The systematic search yielded 38 patients from 35 articles. The median age was 68 [IQR 54, 73] years, and 63.2% of patients were men. A history of heart disease was present in 55.3% of cases, while 15.8% had a history of cardiovascular electronic device implantation. The mitral valve was the most commonly affected site, accounting for 52.8%. The misdiagnosis or missed diagnosis rate of CSIE was 28.9%. Microbiological confirmation by 16S ribosomal ribonucleic acid (16S rRNA) or metagenomic next-generation sequencing (mNGS) was present in 13.2% of cases. Vancomycin was the most effective antibiotic, with 41.7% of the CS isolates showing resistance to multiple drugs. Surgical intervention was performed in 55.3% of the CSIE pati...