Triglyceride-Glucose Index and Neutrophil-to-Lymphocyte Ratio: A Metabolic-Inflammatory Signature for Mortality Prediction in a Multicenter Retrospective Cohort of 1249 Dialysis Patients with Coronary Artery Disease

作者：Yike Li, Peng Li, Qiang Tang, Ting Jiao, Yanxiang Gao, Shuoyan An, Hao Jiang, Hui Cheng, Zixuan Yang, Jiahui Zhou, Yuxuan Sun, Yi‐Ning Yang, Jingang Zheng · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s548327 · 被引用次数：2 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Adipokines, Inflammation, and Metabolic Diseases、Biomarkers in Disease Mechanisms

Introduction: Hyperlipidemia, impaired glucose tolerance, and inflammatory status are critical contributors to the progression of coronary artery disease (CAD). Biomarkers associated with these pathways may predict clinical outcomes in dialysis-dependent CAD patients. This study aims to compare conventional lipid profiles, inflammatory markers, and insulin resistance-related indicators to evaluate their associations with mortality and prognostic performance in this high-risk population. Methods: This multicenter retrospective cohort study included 1249 patients from January 2015 to June 2021. 864 patients were finally included in the analysis. Baseline lipid profiles, inflammatory markers, and insulin resistance-related indicator (the triglyceride-glucose [TyG] index) were analyzed. Results: =0.038) were independently associated with mortality, whereas lipid profiles showed no significant association. Adding the TyG index or NLR to the Global Registry of Acute Coronary Events (GRACE) score (TyG c-index: 0.644 [0.609-0.679]; NLR c-index: 0.642 [0.607-0.677]) or baseline model (TyG c-index: 0.707 [0.676-0.738]; NLR c-index: 0.705 [0.672-0.738]) improved predictive performance. The combined model integrating TyG index and NLR demonstrated the highest discriminative ability for mortality prediction (GRACE score c-index: 0.660 [0.625-0.695]; Baseline model c-index: 0.713 [0.682-0.744]). Conclusion: The findings indicate that systemic inflammation and insulin resistance are more si...