Critical review on bioactive substances from sea food and their health promoting effects

作者：Thusara Wijethunga, Tharuka Wijesekara, Saiyi Zhong, Baojun Xu · 发表于：Journal of Future Foods · 年份：2025 · DOI：10.1016/j.jfutfo.2025.04.022 · 被引用次数：4 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Seaweed-derived Bioactive Compounds、Biochemical effects in animals

• Marine bioactive compounds show strong antimicrobial, anticancer effects etc. • Peptides from seafoods offer potent therapeutic benefits. • Polyketides and alkaloids of seafoods show strong anticancer potential. • Chitosan and omega-3s are key marine compounds with health benefits. • Marine biodiversity is vital for new drug discoveries. Seafood is a valuable source of bioactive compounds with significant therapeutic potential, contributing to human health through diverse biological activities. These compounds, derived from marine organisms such as fish, crustaceans, mollusks, and algae, exhibit antimicrobial, anti-inflammatory, anticancer, antioxidant, neuroprotective, and immunomodulatory properties. The structural diversity of seafood-derived bioactive compounds, shaped by the unique marine environment, often provides novel pharmacological applications. This review explores key classes of bioactive substances, including peptides, polysaccharides, lipids, alkaloids, polyketides, and terpenoids. Marine-derived peptides, such as antimicrobial peptides from crustaceans, have demonstrated broad-spectrum efficacy against bacterial and viral pathogens. Additionally, bioactive peptides exhibit antihypertensive effects by inhibiting angiotensin-converting enzyme (ACE), contributing to cardiovascular health. Polysaccharides such as chitosan, extracted from crustacean shells, and sulfated glycans, derived from marine algae and invertebrates, have shown significant anticancer activi...