Sensory Reweighting Revealed by Superior Parietal Cortex–Based Functional Connectivity in Chronic Ankle Instability: A Resting-State fMRI Study

作者：Xiao’ao Xue, Shanshan Zheng, Zikun Wang, Yushi Chen, Lin Chang, Ziyuan Wang, Chang Liu, Ziyu Lu, Rong Lü, Yang Sun, He Wang, Yinghui Hua · 发表于：Medicine & Science in Sports & Exercise · 年份：2025 · DOI：10.1249/mss.0000000000003762 · 被引用次数：3 · 研究领域：Foot and Ankle Surgery、Lower Extremity Biomechanics and Pathologies、Knee injuries and reconstruction techniques

PURPOSE: Individuals with chronic ankle instability (CAI) are believed to rely more heavily on visual input during postural control due to impaired somatosensory function; however, the neural mechanisms underlying sensory reweighting in CAI are not well understood. This study explored the neural and behavioral correlates of increased visual reliance in CAI through functional connectivity (FC) analysis. METHODS: This cross-sectional study enrolled 37 patients with CAI and 36 healthy individuals. Participants underwent postural stability assessments using the single-leg stance test, both with their eyes open and closed. Traditional and modified Romberg ratios were calculated. Resting-state functional magnetic resonance imaging was used to estimate FC between the superior parietal cortex (SPC) and visual, sensorimotor, and cerebellar regions, as well as the coefficient of variation of these FCs. RESULTS: Compared with healthy individuals, patients with CAI displayed significantly higher visual reliance, as indicated by the traditional and modified Romberg ratios of sway length (Cohen's d = 0.47-0.57). Patients with CAI also exhibited stronger FC between the SPC and higher-level visual cortices (Cohen's d = 0.56-0.62) and more unstable coefficient of variation for FC between the SPC and the cerebellar anterior lobe (Cohen's d = 0.64). Subregion analysis revealed that variability in FC between subregions I-IV of the cerebellar anterior lobe and anterior lateral area 7 of the SPC w...