Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs

作者：Shiqi Wang, Gaiqin Pei, Jiayu Shen, Zhi Fang, Tingyu Chen, Lu Wang, Hongxin Cheng, Hanbin Li, Hongliang Pei, Qipu Feng, Qingwen Fan, Chengqi He, Chenying Fu, Yingqiang Guo, Wei Quan · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.04.019 · 被引用次数：4 · 研究领域：Electromagnetic Fields and Biological Effects、Microbial Inactivation Methods、Ultrasound and Hyperthermia Applications

• PEMF treatment can ameliorate cardiac function and reduce scar size in post-MI mice and pigs. • The benefits of PEMF in the treatment of MI are supported by reduced inflammatory responses, improved cell survival, and decreased collagen secretion. • The underlying molecular mechanism of PEMF treatment is associated with the inhibition of the TLR4/MyD88/NF-κB and TGF-β1/SMAD3 signaling pathways. • From the perspective of safety, the process of PEMF treatment is safe. No adverse events occur. PEMF treatment does not cause damage to liver or kidney function and does not lead to the growth of harmful intestinal flora. • PEMF treatment holds significant promise as a noninvasive physical therapy modality, justifying further exploration of its potential implications for managing patients with IHD. Ischemic heart disease (IHD) is a prominent contributor to mortality worldwide, with myocardial infarction (MI) representing its most severe manifestation. Pulsed electromagnetic fields (PEMF) treatment shows promise for treating IHD. Nevertheless, the therapeutic impact and underlying mechanism of PEMF in MI are not fully understood. To investigate the efficacy, safety, and mechanisms of PEMF for MI. We established MI models in both mice and pigs and performed serial echocardiography and cardiac magnetic resonance follow-up to demonstrate the benefit of PEMF treatment after MI. The pathological environment after myocardial infarction was simulated in vitro to observe changes in various c...