Isolation of Endophytic Fungi and Effects on Secondary Metabolites in Hairy Roots of Salvia miltiorrhiza

作者：Yiming Wang, Shiyu Cai, Tao Zhang, Junzhi Peng, Dan Li, Ludan Li, Xiaoying Cao, Jihong Jiang · 发表于：Journal of Microbiology and Biotechnology · 年份：2025 · DOI：10.4014/jmb.2411.11051 · 被引用次数：5 · 研究领域：Fungal Biology and Applications

the blood, and eliminating irritation and carbuncles [1][2][3][4].It has a long history as a traditional Chinese medicine in China [5,6].Its main components include water-soluble components (such as salvianic acid A) and fat-soluble components (such as tanshinone I), which are commonly used to treat cardiovascular and cerebrovascular diseases, chronic liver disease, cancer, and osteoporosis [7][8][9][10].At present, the main source of S. miltiorrhiza medicinal materials is artificial cultivation, which is difficult to control the quality and varies greatly in quality from region to region [11,12].With the increase in the incidence of cardiovascular diseases in recent years, the demand for S. miltiorrhiza medicinal materials has also exceeded the supply.Endophytic fungi are widely present in plants, and refer to fungi that exist in the living tissues of plants during some or all stages of their life cycle, and do not cause significant disease in the plant itself [13][14][15].They also achieve a dynamic balance of growth with their host to some extent, forming a mutually beneficial relationship [16][17][18].Some endophytic fungi can also positively regulate the biosynthesis of plant secondary metabolites through polysaccharide elicitors [19,20].Hairy roots are a high-quality source of active ingredients in medicinal plants, with the advantages of rapid growth, yields of secondary metabolites similar to those of plant, and high genetic stability [21][22][23].The use of hairy roo...