A pH-responsive fluorescence nanosystem for imaging lipid deposition in diseased aortic valves

作者：Shufen Li, Tian‐Yi Qu, Zheng Chai, Dongxu Yang, Ming Chen, Ying Zhang, Chengming Li, Yongchao Yao, Weihua Zhuang, Walter Hu, Chen Mao · 发表于：Journal of Materials Chemistry B · 年份：2025 · DOI：10.1039/d5tb00531k · 被引用次数：4 · 研究领域：Cardiac Valve Diseases and Treatments、Infective Endocarditis Diagnosis and Management、Aortic Disease and Treatment Approaches

mice after tail vein injection and specifically stained the deposited lipid. Thus, our results demonstrated that ECNBD-loaded nanoparticles could serve as a potential nanoplatform for the diagnosis of VHD and the feasibility of diseased heart valve-targeted delivery of imaging or therapeutic agents.