Addressing challenges in pediatric thrombosis: a comprehensive guideline development

作者：Yin Wang, Qinan Yin, Jace Liao, Wang Na, Li Li, Siyan Li, Qingxia Zhang, Feifei Yu, Jianchun Luo, Hongmei Wang, Dongyu Hu, Wenyi Li, Biao Li, Jingjing Chen, Limei Dong, Min Luo, Yu Yan, Dong Li, Zheng Ding, Xi Wei, Jiadan Yang, Shenglan Tan, Lian Li, Xi Zheng, Liuyun Wu, Yongsheng Yang, Linan Zeng, Jinqi Li, Lizhu Han, Yuan Bian · 发表于：Frontiers in Pediatrics · 年份：2025 · DOI：10.3389/fped.2025.1519517 · 被引用次数：3 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Pharmaceutical studies and practices、Retinopathy of Prematurity Studies

Background: Pediatric thrombosis is a relatively rare but severe condition in the field of pediatrics, with far-reaching consequences. Recent studies have indicated a rising incidence of this disease in children over the years. Additionally, the pharmacological treatment of thrombotic diseases in children faces numerous challenges. Due to significant physiological differences between children and adults, guidelines for the prevention and treatment of thrombotic diseases in adults cannot be directly applied to pediatric patients. Purpose: A systematic review of the existing evidence-based medical literature should be conducted to propose pharmacological prevention and treatment recommendations for pediatric thrombotic diseases. Developing a comprehensive and practical pharmacotherapy guideline for the prevention and treatment of pediatric thrombotic diseases is essential to enhancing the rational use of medications in managing these conditions in children. Methods: The guideline development followed the World Health Organization's (WHO) Handbook for Guideline Development. This involves systematically searching and extensively collecting data on common medication issues in the prevention and treatment of pediatric thrombosis nationwide. The Delphi method was used to survey experts and identify the clinical issues to be included. Subsequently, a systematic literature review was conducted to evaluate existing primary studies, systematic reviews, and guidelines or consensus statem...