Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: A new function and mechanism

作者：Ting Li, Yueyue Liu, Tianchi Duan, Chao Guo, Bin Liu, Xiu‐Qiong Fu, Lu Wang, Xiaoyuan Wang, Xinyue Dong, Chennan Wang, Yalong Lu, Yu Wang, Lin Shi, Honglei Tian, Xingbin Yang · 发表于：Cell Metabolism · 年份：2024 · DOI：10.1016/j.cmet.2024.10.012 · 被引用次数：29 · 研究领域：Extracellular vesicles in disease、Ion Channels and Receptors、Heat shock proteins research

FC < -2) in both mice and human feces following stachyose treatment could specifically suppress the growth of Lactobacillus reuteri. These findings build a new regulatory axis of stachyose-intestinal miRNAs-gut microbiota and unveil a previously unknown mechanism underlying the direct "talk" of oligosaccharides to intestine epithelium via membranous HSP90β.