Unlocking the Therapeutic and Antimicrobial Potential of Prunus armeniaca L. Seed Kernel Oil

作者：Zeenat Hamid, Ali Akbar, Kashif Kamran, Jahangir Khan Achakzai, Ling Shing Wong, Muhammad Bilal Sadiq · 发表于：International Journal of Food Science · 年份：2024 · DOI：10.1155/2024/5589506 · 被引用次数：9 · 研究领域：Essential Oils and Antimicrobial Activity、Phytochemicals and Antioxidant Activities、Nuts composition and effects

The Prunus armeniaca L. (bitter apricot) is an apricot fruit tree categorized on the basis of the bitter taste of its seed kernel. In this study, the functional, medicinal, and therapeutic potential of bitter apricot seed kernel oil (BASKO) was evaluated. The qualitative screening of BASKO was performed using standard methodologies. The chemical profile of the oil was analyzed with the help of Fourier transform infrared (FTIR) and gas chromatography and mass spectrometry (GC‐MS). Results revealed the presence of different phytochemical constituents comprising steroids, flavonoids, terpenoids, alkaloids, and cardiac glycosides. The antioxidant activity of the oil was determined by a 2,2,diphenyl‐1picrylhydrazyl (DPPH) radical inhibition essay. Total phenolic and flavonoid contents were 10.6 ± 1.32 mg GAE/g and 4.75 ± 0.11 mg QE/g, respectively. DPPH inhibition of 89.5% was achieved at 1000 μ g/mL of BASKO, with IC 50 = 90.44 μ g/mL (83.47–96.67 μ g/mL with 95% CI). The antimicrobial potential of the BASKO revealed the inhibition of Escherichia coli (20.3 ± 2.08 mm), Salmonella typhi (19.3 ± 2.51 mm), Klebsiella pneumoniae (16.6 ± 1.52 mm), Pseudomonas aeruginosa (17 ± 2 mm), and Staphylococcus aureus (25 ± 1.01 mm). The minimum inhibitory concentration (MIC) value was 250 μ L/mL for K. pneumoniae , S. typhi , P. aeruginosa , and S. aureus , whereas 62.5 μ L/mL for E. coli . Moreover, BASKO showed antifungal potential against Trichophyton tonsurans (77.3 ± 2.08%), Epidermophyto...