Circular RNA SCMH1 suppresses KMO expression to inhibit mitophagy and promote functional recovery following stroke

作者：Yu Wang, Ying Bai, Yang Cai, Yuan Zhang, Ling Shen, Xi Wen, Zhongqiu Zhou, Lian Xu, Xue Liu, Bing Han, Honghong Yao · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.99323 · 被引用次数：19 · 研究领域：Circular RNAs in diseases、MicroRNA in disease regulation、Nuclear Receptors and Signaling

Our study reveals a novel mechanism by which circSCMH1 downregulates KMO expression, thereby enhancing mitochondrial fusion and inhibiting mitophagy, ultimately facilitating post-stroke brain repair. These findings shed new light on the role of circSCMH1 in promoting stroke recovery and underscore its potential as a therapeutic target for the treatment of ischemic stroke.