Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function

作者：Yiqing Zhu, Borui Chen, Xinyu Zhang, Muhammad Toheed Akbar, Tong Wu, Yiyun Zhang, Zhi Li, Qun Shen · 发表于：Nutrients · 年份：2024 · DOI：10.3390/nu16162660 · 被引用次数：477 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Microbial Metabolites in Food Biotechnology

The gut microbiota are mainly composed of Bacteroidetes and Firmicutes and are crucial for metabolism and immunity. Muribaculaceae are a family of bacteria within the order Bacteroidetes. Muribaculaceae produce short-chain fatty acids via endogenous (mucin glycans) and exogenous polysaccharides (dietary fibres). The family exhibits a cross-feeding relationship with probiotics, such as Bifidobacterium and Lactobacillus. The alleviating effects of a plant-based diet on inflammatory bowel disease, obesity, and type 2 diabetes are associated with an increased abundance of Muribaculaceae, a potential probiotic bacterial family. This study reviews the current findings related to Muribaculaceae and systematically introduces their diversity, metabolism, and function. Additionally, the mechanisms of Muribaculaceae in the alleviation of chronic diseases and the limitations in this field of research are introduced.