Novel fungal diphenyl ether biosynthetic gene clusters encode a promiscuous oxidase for elevated antibacterial activities

作者：Qingpei Liu, Shuaibiao Gao, Jin Fang, Yifu Gong, Yiling Zheng, Yao Xu, Dan Zhang, Jiayuan Wei, Liangxiu Liao, Ming Yao, Wen‐Jing Wang, Xiaole Han, Fusheng Chen, István Molnár, Xiaolong Yang · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d4sc01435a · 被引用次数：8 · 研究领域：Microbial Natural Products and Biosynthesis、Bioactive Compounds and Antitumor Agents、Cholinesterase and Neurodegenerative Diseases

-terminal region of DpeH to alter substrate recognition. Our work highlights an evolutionarily conserved way to produce DPEs, and provides enzymatic tools to generate DPE analogues with broad spectrum antibiotic activity against multidrug-resistant human pathogens.