Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study

作者：Peijie Sun, Xiaojie Guo, Enmin Ding, Chenfeng Li, Huimin Ren, Yibo Xu, Jiankun Qian, Fuchang Deng, Wanying Shi, Haoran Dong, Elizabeth Z. Lin, Pengfei Guo, Jianlong Fang, Qian Zhang, Wenhua Zhao, Shilu Tong, Xiaobo Lu, Krystal J. Godri Pollitt, Xiaoming Shi, Song Tang · 发表于：Environmental Health Perspectives · 年份：2024 · DOI：10.1289/ehp13865 · 被引用次数：12 · 研究领域：Health, Environment, Cognitive Aging、Metabolomics and Mass Spectrometry Studies、Air Quality and Health Impacts

BACKGROUND: Evidence suggested that abiotic airborne exposures may be associated with changes in body composition. However, more evidence is needed to identify key pollutants linked to adverse health effects and their underlying biomolecular mechanisms, particularly in sensitive older adults. OBJECTIVES: Our research aimed to systematically assess the relationship between abiotic airborne exposures and changes in body composition among healthy older adults, as well as the potential mediating mechanisms through the serum lipidome. METHODS: From September 2018 to January 2019, we conducted a monthly survey among 76 healthy adults (60-69 years old) in the China Biomarkers of Air Pollutant Exposure (BAPE) study, measuring their personal exposures to 632 abiotic airborne pollutions using MicroPEM and the Fresh Air wristband, 18 body composition indicators from the InBody 770 device, and lipidomics from venous blood samples. We used an exposome-wide association study (ExWAS) and deletion/substitution/addition (DSA) model to unravel complex associations between exposure to contaminant mixtures and body composition, a Bayesian kernel machine regression (BKMR) model to assess the overall effect of key exposures on body composition, and mediation analysis to identify lipid intermediators. RESULTS: ), of the observed increase in VFA. DISCUSSION: Based on the evidence from multiple model results, ATQ and DMIP were statistically significantly associated with the increased VFA levels of he...