Advancement of Research Progress on Synthesis Mechanism of Cannabidiol (CBD)

作者：Fu Wang, Zhenyuan Zang, Qian Zhao, Chunxiao Xiaoyang, Xiujuan Lei, Ying‐Ping Wang, Yiqiao Ma, Rong‐An Cao, Xixia Song, Lili Tang, Michael K. Deyholos, Jian Zhang · 发表于：ACS Synthetic Biology · 年份：2024 · DOI：10.1021/acssynbio.4c00239 · 被引用次数：9 · 研究领域：Cannabis and Cannabinoid Research、Pancreatic function and diabetes、Diet, Metabolism, and Disease

L. is a multipurpose crop with high value for food, textiles, and other industries. Its secondary metabolites, including cannabidiol (CBD), have potential for broad application in medicine. With the CBD market expanding, traditional production may not be sufficient. Here we review the potential for the production of CBD using biotechnology. We describe the chemical and biological synthesis of cannabinoids, the associated enzymes, and the application of metabolic engineering, synthetic biology, and heterologous expression to increasing production of CBD.