Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling

作者：Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Ping Jian, Hua Zhang, Yongping Mu, Chenghai Liu, Chao‐Po Lin, Jian Wu, Ping Liu, Jiamei Chen · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.91572 · 被引用次数：25 · 研究领域：Hedgehog Signaling Pathway Studies、Liver physiology and pathology、Digestive system and related health

During various modes of chronic injury, Gli1 acted as an important mediator of HPC activation, expansion, differentiation into reactive cholangiocytes that formed DR, and subsequently provoked hepatic fibrogenesis.