Design, synthesis and antibacterial evaluation of N -substituted indole derivatives containing 1,3,4-thiadiazole and amide moieties

作者：Chenghao Tang, Chou Si, Yidan Zhang, Shengzhou Yang, Xingju Chen, Pei Li, Xiang Wang · 发表于：Phosphorus, sulfur, and silicon and the related elements · 年份：2024 · DOI：10.1080/10426507.2024.2318584 · 被引用次数：3 · 研究领域：Synthesis and biological activity、Synthesis and Biological Evaluation、Multicomponent Synthesis of Heterocycles

A total of eighteen novel 2-(1H-indol-1-yl)-N-(5-phenyl-1,3,4-thiadiazol-2-yl) acetamide derivatives were synthesized through the condensation reaction of 2-(1H-indol-1-yl) acetic acid and 5-phenyl-1,3,4-thiadiazol-2-amine via fragment-based design strategy. The target compounds were subjected to screening for antibacterial activity against Xanthomonas oryzae pv. Oryzae, Xanthomonas axonopodis pv. Citri and Pseudomonas syringae pv. Actinidiae. The preliminary antibacterial evaluation of the target compounds showed that some target compounds possessed moderate to good activities against Xoo and Xac. Among them, compound 3p exhibited best inhibition effects against Xoo (77.85% and 62.15%, respectively) and Xac (52.51% and 36.48%, respectively) at 100 μg/mL and 50 μg/mL, which were superior to Thiodiazole-copper and Bismerthiazol. To the best of our knowledge, it is the first report on the design, synthesis, and antibacterial evaluation of novel indole-derived compounds containing 1,3,4-thiadiazole and amide moieties.