Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives

作者：Qianqian Sun, Hongxiao Li, Xingyu Chen, Jian Hao, Hongmei Deng, Haizhen Jiang · 发表于：Molecules · 年份：2023 · DOI：10.3390/molecules28083578 · 被引用次数：4 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions

A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions.