Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China

作者：Yannan Chen, Jiawei Qin, Liyuan Tao, Zhizhen Liu, Jia Huang, Weilin Liu, Ying Xu, Qiang Tang, Yongguo Liu, Zhuhong Chen, Shangjie Chen, Shengxiang Liang, Cong Chen, Jinjin Xie, Jue Liu, Lidian Chen, Jing Tao · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.7004 · 被引用次数：114 · 研究领域：Balance, Gait, and Falls Prevention、Stroke Rehabilitation and Recovery、Dementia and Cognitive Impairment Research

Importance: Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan has better long-term benefits than fitness walking in cognitive function for patients with T2D and mild cognitive impairment (MCI). Objective: To compare the effectiveness of tai chi chuan, a mind-body exercise, for improving cognitive function in older adults with T2D and MCI, with fitness walking. Design, Setting, and Participants: This randomized clinical trial was conducted between June 1, 2020, and February 28, 2022, at 4 sites in China. Participants included 328 adults (aged ≥60 years) with a clinical diagnosis of T2D and MCI. Interventions: Participants were randomized in a 1:1:1 ratio to a tai chi chuan group, a fitness walking group, or a control group. The tai chi chuan group received 24-form simplified tai chi chuan. The fitness walking group received fitness walking training. Both exercise groups took the training for 60 min/session, 3 times/wk, for 24 weeks in a supervised setting. All 3 groups were provided with a 30-minute diabetes self-management education session, once every 4 weeks for 24 weeks. The participants were followed up for 36 weeks. Main Outcomes and Measures: The primary outcome was the global cognitive function measured at 36 weeks by the Montreal Cognitive Assessment (MoCA). Secondary outcomes included MoCA at 24 weeks and other cogniti...