Mechanismbased role of the intestinal microbiota in gestational diabetes mellitus: A systematic review and meta-analysis

作者：Min Yan, Xiaoying Guo, Guiyuan Ji, Rui Huang, Dongyi Huang, Li Z, Dantao Zhang, Siyi Chen, Rong Cao, Xingfen Yang, Wei Wu · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2022.1097853 · 被引用次数：57 · 研究领域：Gut microbiota and health、Gestational Diabetes Research and Management、Pelvic floor disorders treatments

Background Metabolic disorders caused by intestinal microbial dysregulation are considered to be important causes of gestational diabetes mellitus (GDM). Increasing evidence suggests that the diversity and composition of gut microbes are altered in disease states, yet the critical microbes and mechanisms of disease regulation remain unidentified. Methods PubMed ® (National Library of Medicine, Bethesda, MD, USA), Embase ® (Elsevier, Amsterdam, the Netherlands), the Web of Science™ (Clarivate™, Philadelphia, PA, USA), and the Cochrane Library databases were searched to identify articles published between 7 July 2012 and 7 July 2022 reporting on case–control and controlled studies that analyzed differences in enterobacteria between patients with GDM and healthy individuals. Information on the relative abundance of enterobacteria was collected for comparative diversity comparison, and enterobacterial differences were analyzed using random effects to calculate standardized mean differences at a p -value of 5%. Results A total of 22 studies were included in this review, involving a total of 965 GDM patients and 1,508 healthy control participants. Alpha diversity did not differ between the participant groups, but beta diversity was significantly different. Firmicutes , Bacteroidetes , Actinobacteria , and Proteobacteria were the dominant bacteria, but there was no significant difference between the two groups. Qualitative analysis showed differences between the groups in the Firmic...