Anticarcinogenic potentials of tea catechins

作者：Xiaoxiang Li, Chang Liu, Shuling Dong, Can-Song Ou, Jian‐Liang Lu, Jian‐Hui Ye, Yue‐Rong Liang, Xin‐Qiang Zheng · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.1060783 · 被引用次数：58 · 研究领域：Tea Polyphenols and Effects、Tannin, Tannase and Anticancer Activities、Cancer, Stress, Anesthesia, and Immune Response

Catechins are a cluster of polyphenolic bioactive components in green tea. Anticarcinogenic effects of tea catechins have been reported since the 1980s, but it has been controversial. The present paper reviews the advances in studies on the anticarcinogenic activities of tea and catechins, including epidemiological evidence and anticarcinogenic mechanism. Tea catechins showed antagonistic effects on many cancers, such as gynecological cancers, digestive tract cancers, incident glioma, liver and gallbladder cancers, lung cancer, etc. The mechanism underlying the anticarcinogenic effects of catechins involves in inhibiting the proliferation and growth of cancer cells, scavenging free radicals, suppressing metastasis of cancer cells, improving immunity, interacting with other anticancer drugs, and regulating signaling pathways. The inconsistent results and their causes are also discussed in this paper.