Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

作者：Matthew T. N. Yarnall, Eleonora Ioannidi, Cian Schmitt-Ulms, Rohan N. Krajeski, Justin Lim, Lukas Villiger, Wenyuan Zhou, Kaiyi Jiang, Sofya K. Garushyants, Nathaniel Roberts, Liyang Zhang, Christopher A. Vakulskas, John Walker, Anastasia P. Kadina, Adrianna E. Zepeda, Kevin Holden, Hong Ma, Jun Xie, Guangping Gao, Lander Foquet, Greg Bial, Sara K. Donnelly, Yoshinari Miyata, Daniel R. Radiloff, Jordana M. Henderson, Andrew Ujita, Omar O. Abudayyeh, Jonathan S. Gootenberg · 发表于：Nature Biotechnology · 年份：2022 · DOI：10.1038/s41587-022-01527-4 · 被引用次数：450 · 研究领域：CRISPR and Genetic Engineering、Cytomegalovirus and herpesvirus research、HIV Research and Treatment