Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin

作者：Xinlong He, Wenwen Zhang, Qingchao Cao, Yinyue Li, Guangyu Bao, Tao Lin, Jiaojiao Bao, Caiwang Chang, Changshui Yang, Yi Yin, Jiahui Xu, Zhenyu Ren, Yingshan Jin, Feng Lü · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.02782-22 · 被引用次数：16 · 研究领域：Bacterial biofilms and quorum sensing、Antimicrobial Resistance in Staphylococcus、Antimicrobial Peptides and Activities

In this study, the synergistic antibacterial and antibiofilm effects of the traditional herb C. ambrosioides L. and the classic antibiotic penicillin G on MRSA provide a potential strategy to deal with the rapid development of MRSA antibiotic resistance. This study also provides a theoretical basis for further optimizing the combined effect of kaempferol rhamnosides, quercetin, and penicillin G and exploring anti-MRSA biofilm infection research with SarA and σB as drug targets.