Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder

作者：Liang Liu, Haibo Yuan, Qiang Wang, Chuangui Li · 发表于：Journal of Oncology · 年份：2022 · DOI：10.1155/2022/8594022 · 被引用次数：9 · 研究领域：Bladder and Urothelial Cancer Treatments、Urinary and Genital Oncology Studies、Esophageal Cancer Research and Treatment

Objective. To assess the prognosis of stage IV metastatic urinary bladder urothelial carcinoma (UBUC) at initial diagnosis and determine prognostic factors based on distant organ metastasis. Methods. A retrospective cohort analysis of UBUC was conducted based on the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression analyses were used to determine the variables associated with overall survival (OS). Kaplan–Meier curves were used to compare survival curves among different groups. Results. A total of 3103 patients with stage IV UBUC were selected for analysis. The number of distant organ metastatic sites independently predicted the OS. The OS was not different in other metastatic sites when bone metastasis was used as a reference P > 0.05 . However, the OS was shorter for a single metastatic site P < 0.001 and multiple metastatic sites when metastasis was not used as a reference P < 0.001 . Multivariable Cox regression analysis indicated that low survivorship was independently associated with no surgery for the entire cohort and patients with only one metastatic organ. Sex (P = 0.019) and grade (P = 0.046) were the independent risk factors for patients with only one metastatic organ. Conclusions These results show that the prognosis of stage IV metastatic UBUC is not different between any single metastatic organ. The prognosis of stage IV metastatic UBUC depends o...