IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 In Vitro

作者：Siyi Xu, Jinlan Huang, Zhen Xun, Shiqi Li, Ya Fu, Ni Lin, Wennan Wu, Tianbin Chen, Can Liu, Qishui Ou · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.01557-22 · 被引用次数：21 · 研究领域：Hepatitis C virus research、Hepatitis B Virus Studies、Liver Disease Diagnosis and Treatment

Our study contributes new insights into the understanding of the functions and roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), which is one of the interferon-stimulated genes induced by hepatitis B virus infection in human hepatocytes and hepatocarcinoma cells, and may help to identify targeted genes promoting the efficacy of interferon alpha.