Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study

作者：Qianqian Si, Yuming Teng, Caiyan Liu, Weizhuang Yuan, Xiaoyuan Fan, Xiaoqian Zhang, Zongmuyu Zhang, Mingli Li, Qing Liu, Peng Wang, Zhongrui Yan, Bo Wu, Qiang Liu, Hangjuan Li, Yan Ji, Yuncai Ran, Bo Song, Shiguang Zhu, Hongyan Li, Jingxia Guan, Manli Zhao, Yonggang Hao, Pengfei Wang, Hong Bian, Ningfen Wang, Yulin Wang, Yuning Pan, Hongwei An, Rong Guo, Cong Han, Junshi Zhang, Hebo Wang, Yong You, Hongquan Jiang, Zifan Liu, Jingli Liu, Dingbo Tao, Hulin Piao, Jiangtao Zhang, Pei Wang, Shen Yang, Zhou Liu, Xiue Wei, Kai Han, Zhimin Shi, Aihua Liu, Zuowen Zhang, Chunye Ma, Baichen Wang, Gejuan Zhang, Chengguang Song, Guilian Zhang, Xiao Jin Yang, Bing Chen, Baoquan Lu, Beilei Chen, Meng Zuo, Kun Han, Xiaodan Zhang, Wenfeng Cao, Lingfeng Wu, Qi Li, Xiaokun Geng, Junshan Zhou, Mengfei Zhong, Minghua Wang, Yangmei Chen, Jiachun Liu, Tingrui Wang, Youqing Deng, Weihai Xu · 发表于：Annals of Translational Medicine · 年份：2022 · DOI：10.21037/atm-22-3570 · 被引用次数：8 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Neurological and metabolic disorders、Moyamoya disease diagnosis and treatment

Background: Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes of stroke worldwide. Current diagnostic evaluations and treatments remain insufficient to assess the vulnerability of intracranial plaques and reduce the recurrence of stroke in symptomatic ICAS. On the other hand, asymptomatic ICAS is associated with an increased risk of cognitive impairment. The pathogenesis of ICAS related cognitive decline is largely unknown. The aim of SICO-ICAS study (stroke incidence and cognitive outcomes of ICAS) is to elucidate the pathophysiology of stroke and cognitive impairment in ICAS population, comprehensively evaluating the complex interactions among life-course exposure, genomic variation, vascular risk factors, cerebrovascular burden and coexisting neurodegeneration. Methods: SICO-ICAS is a multicenter, prospective, observational cohort study. We aim to recruit 3,000 patients with symptomatic or asymptomatic ICAS (>50% or occlusion) who will be followed up for ≥12 months. All participants will undergo pre-designed magnetic resonance imaging packages, blood biomarkers testing, as well as detailed cognitive domains assessment. All participants will undergo clinical visits every 6 months and telephone interviews every 3 months. The primary outcome measurement is ischemic stroke or cognitive impairment within 12 months after enrollment. Discussion: This study will establish a large prospective ICAS cohort, hopefully discover new biomarkers associated with vul...