Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition

作者：Xu‐Cong Lv, Qi Wu, Ying-Jia Cao, Yichen Lin, Weiling Guo, Pingfan Rao, Yanyan Zhang, Youting Chen, Lianzhong Ai, Li Ni · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d1fo03219d · 被引用次数：103 · 研究领域：Fungal Biology and Applications、Medicinal Plants and Bioactive Compounds、Pharmacological Effects of Natural Compounds

. Furthermore, liver metabolomics based on UPLC-QTOF/MS demonstrated that oral administration of GAA had a significant regulatory effect on the composition of liver metabolites in mice exposed to alcohol intake, especially the levels of the biomarkers involved in the metabolic pathways of riboflavin metabolism, glycine, serine and threonine metabolism, pyruvate metabolism, glycolysis/gluconeogenesis, biosynthesis of unsaturated fatty acids, synthesis and degradation of ketone bodies, fructose and mannose metabolism. Moreover, dietary supplementation of GAA significantly regulated the hepatic mRNA levels of lipid metabolism and inflammatory response related genes. Conclusively, these findings demonstrate that GAA has beneficial effects on alleviating alcohol-induced liver injury and is expected to become a new functional food ingredient for the prevention of alcoholic liver injury.