The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis

作者：Hong Jiang, Yahui Fan, Juan Li, Jiaqi Wang, Liyun Kong, Lina Wang, Zhaofang Li, Mei Ma, Xin Shi, Sijiao Liu, Jia Shi, Hailu Zhu, Xiaohong Liu, Le Ma · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.745390 · 被引用次数：13 · 研究领域：Retinal Diseases and Treatments、Antioxidant Activity and Oxidative Stress、Ophthalmology and Visual Impairment Studies

Background and Purpose Data from studies support a beneficial effect of carotenoids and vitamins on an age-related macular degeneration (AMD) risk. However, studies on the relations between blood levels of these nutrients and AMD are limited and provided conflicting results. The objective of this case-control study and meta-analysis was to examine whether the blood concentrations of carotenoids and vitamins were associated with the risk of AMD. Methods A total of 164 cases of AMD and an equal number of controls are individually matched according to age and gender among the participants, who provided blood samples in the Xi'an Eye Study. Plasma carotenoids and vitamins were measured using reversed-phase high-performance liquid chromatography. Bonferroni-corrected covariate-adjusted conditional logistic regression were used to estimate AMD risk by category of these nutrients in the multivariable-adjusted model. Nine studies were identified for the meta-analysis and calculated pooled risk estimates by means of a random-effects model. Results Plasma concentrations of examined carotenoids and vitamins were significantly lower in patients with AMD than those in controls. Plasma concentrations of examined carotenoids and vitamins were significantly lower in patients with AMD than those in controls. After a multivariate adjustment for body mass index, blood cholesterol, and other lifestyle risk factors, higher lutein/zeaxanthin content in plasma was significantly associated with a de...