Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers

作者：Peng Zhao, Linghang Zhuang, Xiangzhu Wang, Song Huang, He‐Ping Wu, Yu Zhou, Yuna Yan, Fan Zhang, Ru Shen, Jing Li, Suxing Liu, Rumin Zhang, Ping Dong, Yuchang Mao, Yuanmin Fan, Chunyong He, Jiakang Sun, Lei Zhang, Qiyue Hu, Hong Wan, Jun Feng, Chang Bai, Feng He, Weikang Tao · 发表于：European Journal of Medicinal Chemistry · 年份：2021 · DOI：10.1016/j.ejmech.2021.114040 · 被引用次数：13 · 研究领域：Computational Drug Discovery Methods、Melanoma and MAPK Pathways、Synthesis and biological activity