Jiakang Sun

机构：Jiangsu Hengrui Medicine (China) · ORCID：0000-0003-0906-4740

发表论文 7 篇 · 总被引 102 次 · h-index 5

代表论文

• Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis (2014 · Journal of Medicinal Chemistry · 被引 32)
• Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis (2021 · Scientific Reports · 被引 25)
• SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, efficient tumor killing potency, and favorable safety profiles (2025 · PLoS ONE · 被引 17)
• Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers (2021 · European Journal of Medicinal Chemistry · 被引 14)
• Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood–Brain Barrier Penetration (2019 · ACS Medicinal Chemistry Letters · 被引 12)
• SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, superior bystander killing effect and favorable safety profiles (2023 · Research Square · 被引 2)