Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness

作者：Bastiaan W. Haak, Ricard Argelaguet, Cormac M. Kinsella, Robert F. J. Kullberg, Jacqueline M. Lankelma, Martin Deijs, Michelle Klein, Maarten F. Jebbink, Floor Hugenholtz, Sarantos Kostidis, Martin Giera, Theodorus B. M. Hakvoort, Wouter J. de Jonge, Marcus J. Schultz, Tom van Gool, Tom van der Poll, Willem M. de Vos, Lia M. van der Hoek, W. Joost Wiersinga · 发表于：mSystems · 年份：2021 · DOI：10.1128/msystems.01148-20 · 被引用次数：80 · 研究领域：Gut microbiota and health、Bacteriophages and microbial interactions、Genomics and Phylogenetic Studies

, we confirm these observations in humans using an integrative analytic approach. These findings underscore the potential value of multi-omics data integration tools in interrogating how different components of the microbiota contribute to disease states. In addition, our findings suggest that there is value in further studying potential adjunctive therapies using anaerobic bacteria or SCFAs to reduce fungal expansion after antibiotic exposure, which could ultimately lead to improved outcomes in the intensive care unit (ICU).