Antibody seroprevalence in the epicenter Wuhan, Hubei, and six selected provinces after containment of the first epidemic wave of COVID-19 in China

作者：Zhongjie Li, Xuhua Guan, Naiying Mao, Huiming Luo, Ying Qin, Na He, Zhen Zhu, Jianxing Yu, Yu Li, Jianhua Liu, Zhijie An, Wenjing Gao, Xiaoli Wang, Xiaodong Sun, Tie Song, Xingfen Yang, Ming Wu, Xianping Wu, Wenqing Yao, Zhibin Peng, Junling Sun, Liping Wang, Qing Guo, Nijuan Xiang, Jun Liu, Bike Zhang, Xuemei Su, Lance E. Rodewald, Liming Li, Wenbo Xu, Hongbing Shen, Zijian Feng, George F. Gao · 发表于：The Lancet Regional Health - Western Pacific · 年份：2021 · DOI：10.1016/j.lanwpc.2021.100094 · 被引用次数：57 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、SARS-CoV-2 detection and testing

Background China implemented containment measures to stop SARS-CoV-2 transmission in response to the COVID-19 epidemic. After the first epidemic wave, we conducted population-based serological surveys to determine extent of infection, risk factors for infection, and neutralization antibody levels to assess the real infections in the random sampled population. Methods We used a multistage, stratified cluster random sampling strategy to conduct serological surveys in three areas - Wuhan, Hubei Province outside Wuhan, and six provinces selected on COVID-19 incidence and containment strategy. Participants were consenting individuals >1 year old who resided in the survey area >14 days during the epidemic. Provinces screened sera for SARS-CoV-2-specific IgM, IgG, and total antibody by two lateral flow immunoassays and one magnetic chemiluminescence enzyme immunoassay; positive samples were verified by micro-neutralization assay. Findings We enrolled 34,857 participants (overall response rate, 92%); 427 were positive by micro-neutralization assay. Wuhan had the highest weighted seroprevalence (4•43%, 95% confidence interval [95%CI]=3•48%-5•62%), followed by Hubei-ex-Wuhan (0•44%, 95%CI=0•26%-0•76%), and the other provinces (<0•1%). Living in Wuhan (adjusted odds ratio aOR=13•70, 95%CI= 7•91–23•75), contact with COVID-19 patients (aOR=7•35, 95%CI=5•05–10•69), and age over 40 (aOR=1•36, 95%CI=1•07–1•72) were significantly associated with SARS-CoV-2 infection. Among seropositives, 101 ...