Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent

作者：Lihua Deng, Hai Jiang, Fulin Lu, Hanwei Wang, Yu Pu, Changqiang Wu, Tang Hong-jie, Ye Xu, Tian‐wu Chen, Jiang Zhu, Chengyi Shen, Xiaoming Zhang · 发表于：International Journal of Nanomedicine · 年份：2021 · DOI：10.2147/ijn.s271461 · 被引用次数：36 · 研究领域：Nanoparticle-Based Drug Delivery、Characterization and Applications of Magnetic Nanoparticles、Lanthanide and Transition Metal Complexes

Objective: PEGylated superparamagnetic iron oxide (SPIO) is the most promising alternatives to gadolinium-based contrast agents (GBCAs) in MRI. This paper is to explore the imaging effects of PEGylated SPIO, which is influenced by particle sizes and surface polyethylene glycol (PEG) coating, using as MRI contrast agents at different magnetic field intensities. Methods: Firstly, nine PEGylated monocrystalline SPIO nanoparticles with different nanocrystal sizes and different molecular weights PEG coating were prepared, and then physical and biological properties were analyzed. Finally, MRI imaging in vivo was performed to observe the imaging performance. Results: Nine PEGylated monocrystalline SPIO nanoparticles have good relaxivities, serum stability, and biosecurity. At the same time, they show different imaging characteristics at different magnetic field intensities. Eight-nanometer [email protected] is an effective T 2 contrast agent at 3.0 T ( r 2 / r 1 = 14.0), is an ideal T 1 - T 2 dual-mode contrast agent at 1.5 T ( r 2 / r 1 = 6.52), and is also an effective T 1 contrast agent at 0.5 T ( r 2 / r 1 = 2.49), while 4-nm [email protected] is a T 1 - T 2 dual-mode contrast agent at 3.0 T ( r 2 / r 1 = 5.24), and is a useful T 1 contrast agent at 0.5 T ( r 2 / r 1 = 1.74) and 1.5 T ( r 2 / r 1 = 2.85). MRI studies in vivo at 3.0 T further confirm that 4-nm [email protected] displays excellent T 1 - T 2 dual-mode contrast enhancement, whereas 8-nm [email protected] only displ...