Cardamine hupingshanensis aqueous extract improves intestinal redox status and gut microbiota in Se‐deficient rats

作者：Yuxin Cheng, Yu‐Ting Huang, Kunyuan Liu, Siyi Pan, Zhiguo Qin, Ting Wu, Xiaoyun Xu · 发表于：Journal of the Science of Food and Agriculture · 年份：2020 · DOI：10.1002/jsfa.10707 · 被引用次数：12 · 研究领域：Selenium in Biological Systems、Arsenic contamination and mitigation、Antioxidants, Aging, Portulaca oleracea

BACKGROUND: As an essential trace element for mammalian species, selenium (Se) possesses powerful antioxidant properties and is a potential regulator of intestinal microbiota. However, effects of Cardamine hupingshanensis aqueous extract (CE), rich in Se, on balancing the intestinal redox status and regulating gut microbiota have been neglected. RESULTS: An Se-deficient rat model was established by feeding a low-Se diet (LD) for 5 weeks and CE was then supplemented to LD or normal-Se-diet (ND) rats. Antioxidant enzyme activities and short-chain fatty acids (SCFA) concentration were increased by CE in both LD and ND rats. CE improved the intestinal morphology of LD rats impaired by deficient Se. Intestinal microbiota demonstrated various changes; for example, Butyrivibrio was increased in LD rats, while Bacteroides, Christensenellaceae, Clostridiaceae and Blautia were enhanced in ND rats. CONCLUSION: Our findings provide evidence that CE shows potential in improving intestinal redox status and regulating gut microbiota. © 2020 Society of Chemical Industry.