Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9

作者：Gigi C.G. Choi, Peng Zhou, Chaya T. L. Yuen, Becky K.C. Chan, Feng Xu, Siyu Bao, Hoi Yee Chu, Dawn Thean, Kaeling Tan, Koon Ho Wong, Zongli Zheng, Alan S.L. Wong · 发表于：Nature Methods · 年份：2019 · DOI：10.1038/s41592-019-0473-0 · 被引用次数：64 · 研究领域：CRISPR and Genetic Engineering、RNA and protein synthesis mechanisms、Insect symbiosis and bacterial influences