Convenient Synthesis of Acyclic Amidines via Copper‐Catalyzed C(sp 3 )‐H Amidination

作者：Wei He, Yao Wu, Dianke Xie, Yun Chen, Wenbing Sheng, Yuan Liu, Guiming Xu, Jiang Xiao, Qiang Liu, Can‐Cheng Guo · 发表于：ChemistrySelect · 年份：2019 · DOI：10.1002/slct.201900226 · 被引用次数：3 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Chemical Synthesis and Analysis

Abstract A convenient synthetic approach for the synthesis of α‐oxo‐acetamidines via copper‐catalyzed C(sp 3 )‐H amidination has been developed. This approach allows the direct amidination of three C(sp 3 )‐H bonds without cyclization.Methyl ketones and primary and secondary amines are tolerant and afford the corresponding products in moderate to good yields. Furthermore, this protocol is also applicable to the synthesis of unsymmetrical α‐oxo‐acetamidines via one‐pot, multicomponent reactions (MCRs).